Oral tumors and neoplastic lesions include 7 percent of all canine neoplasms. Since they can easily invade the associated bone as well as lymph nodes, therefore early detection that highlights the importance of their definite diagnosis is essential in every dental practice. Also, laboratory results play an important role not only in treatment but also in prognosis and they can sometimes work as a prognostic factor. 82 dogs affected with oral lesions were referred to dental pet center for further evaluation and/or treatment in a 16 -month period. The performed procedures include either surgical intervention or incisional biopsy. Lab results including CBC and biochemistry profile obtained prior to surgery. The aim of evaluation of lab results were to find any possible correlation in measured hematologic and biochemistry parameters in the incidence of oral tumors that could be possible use as the prognostic factors. Size, demography of the lesion, sex, age, histopathologic result, challenges of diagnosis and treatment evaluated. No significant difference was found between the incidence of tumor in male and female dogs. Mean age of the dogs affected with oral tumor was about 9 years and malignant tumors account 39 percent of all detected oral lesions. Among them SCC was the most diagnosed malignant tumor and can be the most confusing one with oral ameloblastoma. 4 patients and 33 patients showed lung metastasis and regional lymph nodes invasion at the time of diagnosis respectively. The most recognized challenge was the resistance of the owner and even the veterinarian to perform the surgery and therefore, the tumor grow and metastasized at the time of diagnosis. Thus, malpractice prior to referral observed in about 40 percent of oral tumors which seems considerably high. Neutrophil to lymphocyte ratio as well as number of platelets increased in malignant tumors compared to non-malignant ones. Shih Tzu and Spitz were the commonly affected breed in the list.